Association of H-Type Hypertension with miR-21, miR-29, and miR-199 in Kazahks of Xinjiang, China.

IF 1.9 4区医学 Q3 PERIPHERAL VASCULAR DISEASE

International Journal of Hypertension Pub Date : 2022-09-26 eCollection Date: 2022-01-01 DOI:10.1155/2022/4632087

Xin He, RuLin Ma, Yu Li, Haixia Wang, YiZhong Yan, YiDan Mao, ShengYu Liao, XueYing Sun, ShuXia Guo, Heng Guo

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Abstract

Objective: This study aims to analyze the expressions of miR-21, miR-29, and miR-199 in the serum of the patients with H-type hypertension among Kazakhs. Then, we analyzed the effect of MTHFR 677C > T polymorphism on the association between the above miRNA and H-type hypertension.

Method: In this study, the expression of miR-21, miR-29, and miR-199 was quantitatively measured in 120 serum samples and then stratified according to the C677T polymorphism to analyze the relationship between target miRNAs and HHcy.

Results: The expression of miR-21/-29 in the hypertension group was higher than the normal group (P < 0.001). And the expression of miR-199 was higher in the hcy group than in the normal group (P < 0.001). In the CC and CT genotypes of MTHFR 677C > T, the expression of miR-21 was lower in the HHcy patients than in the normal individuals (P = 0.005 and P = 0.001) and miR-199 was significantly higher in the HHcy patients than in the normal ones (P = 0.002 and P = 0.048). No such difference was found in the TT genotype. Logistic regression analysis showed that after adjusting for sex, age, BMI, systolic blood pressure, diastolic blood pressure, and MTHFRC677 T gene polymorphism, miR-21 was negatively correlated with hcy (OR = 0.222, 95% CI (0.101-0.485), P < 0.001) and miR-199 was positively correlated with hcy (OR = 1.823,95%CI (1.272∼2.614), P = 0.001).

Conclusion: miR-21, miR-29, and miR-199 are associated with H-type hypertension in the Kazakhs, especially hyperhomocysteinemia. And these three miRNAs may serve as biomarkers to provide clues to the potential pathogenesis of H-type hypertension.

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中国新疆哈萨克族人h型高血压与miR-21、miR-29和miR-199的关系

目的:本研究旨在分析哈萨克族h型高血压患者血清中miR-21、miR-29、miR-199的表达。然后，我们分析MTHFR 677C > T多态性对上述miRNA与h型高血压相关性的影响。方法:本研究在120份血清样本中定量检测miR-21、miR-29、miR-199的表达，并根据C677T多态性进行分层，分析靶mirna与HHcy的关系。结果:高血压组miR-21/-29表达明显高于正常组(P < 0.001)。hcy组miR-199的表达高于正常组(P < 0.001)。在MTHFR 677C > T的CC和CT基因型中，HHcy患者中miR-21的表达低于正常人(P = 0.005和P = 0.001)， miR-199在HHcy患者中显著高于正常人(P = 0.002和P = 0.048)。在TT基因型中没有发现这种差异。Logistic回归分析显示，在调整性别、年龄、BMI、收缩压、舒张压和MTHFRC677 T基因多态性后，miR-21与hcy呈负相关(OR = 0.222, 95%CI (0.101 ~ 0.485)， P < 0.001)， miR-199与hcy呈正相关(OR = 1.823,95%CI (1.272 ~ 2.614)， P = 0.001)。结论:miR-21、miR-29和miR-199与哈萨克族人的h型高血压有关，尤其是高同型半胱氨酸血症。这3种mirna可能作为生物标志物，为h型高血压的潜在发病机制提供线索。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Hypertension Medicine-Internal Medicine

CiteScore

4.00

自引率

5.30%

发文量

期刊介绍： International Journal of Hypertension is a peer-reviewed, Open Access journal that provides a forum for clinicians and basic scientists interested in blood pressure regulation and pathophysiology, as well as treatment and prevention of hypertension. The journal publishes original research articles, review articles, and clinical studies on the etiology and risk factors of hypertension, with a special focus on vascular biology, epidemiology, pediatric hypertension, and hypertensive nephropathy.