Hormonal changes in consecutive clomiphene citrate stimulation cycles and their effect on pregnancy rates.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2022-09-23 DOI:10.4274/tjod.galenos.2022.40607

Evrim Ebru Kovalak, Eser Şefik Özyürek, Özlem Karabay Akgül, Tolga Karacan

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引用次数: 2

Abstract

Objective: To determine the relationship between the cumulative effect of sequential clomiphene citrate (CC) treatments in unexplained infertile women with intercycle and intracycle serum hormone changes.

Materials and methods: Patients who received CC 50 mg in the first cycle (group I, n=34) as ovulation induction and those who received CC 50 mg in the second consecutive cycle (group II, n=18) were compared. Basal (cycle days 2-5) and trigger day (the day that recombinant human chorionic gonadotropin is given) levels of gonadotropin and steroid hormones were measured.

Results: The 17OHP increase on trigger day was found to be statistically significantly higher in group II compared to the basal day (p=0.083). The testosterone (T) response on the trigger day of the patients in group II was found to be statistically significantly higher than that in group I (p=0.023). The number of selected follicles was negatively correlated with a follicle-stimulating hormone decrease and positively correlated with an estradiol increase. Endometrial thickness was positively correlated with a luteinizing hormone increase, and cycle cancelation was positively correlated with decreased estradiol.

Conclusion: Based on this study, it was concluded that the reason for the increased efficiency rate in successive cycles of CC may be the cumulative increase in T and 17OHP levels. However, this result was found not to affect the clinical pregnancy rate.

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克罗米芬连续刺激周期的激素变化及其对妊娠率的影响。

目的:探讨枸橼酸克罗米芬序次治疗对月经周期间和月经周期内血清激素改变的不明原因不孕症患者累积效应的关系。材料与方法:比较第一个周期接受cc50mg促排卵患者(I组，n=34)与连续第二个周期接受cc50mg促排卵患者(II组，n=18)。测定基础(周期2-5天)和触发日(给予重组人绒毛膜促性腺激素的当天)促性腺激素和类固醇激素水平。结果:与基础日相比，II组触发日17OHP升高有统计学意义(p=0.083)。II组患者在触发日的睾酮(T)反应明显高于I组(p=0.023)。选择的卵泡数量与促卵泡激素的减少呈负相关，与雌二醇的增加呈正相关。子宫内膜厚度与促黄体生成素增加正相关，周期取消与雌二醇降低正相关。结论:CC连续循环效率提高的原因可能是T和17OHP水平的累积升高。然而，发现该结果不影响临床妊娠率。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.