Oral and Lower Extremity Ulcers as the Initial Presentation of Granulomatosis with Polyangiitis.

IF 0.8 Q3 MEDICINE, GENERAL & INTERNAL

Case Reports in Medicine Pub Date : 2022-08-31 eCollection Date: 2022-01-01 DOI:10.1155/2022/2737242

Mohammed Omar Al Salihi, Bianca Dominguez, Viresh Mohanlal, S J Carlan

{"title":"Oral and Lower Extremity Ulcers as the Initial Presentation of Granulomatosis with Polyangiitis.","authors":"Mohammed Omar Al Salihi, Bianca Dominguez, Viresh Mohanlal, S J Carlan","doi":"10.1155/2022/2737242","DOIUrl":null,"url":null,"abstract":"Background: Granulomatosis with polyangiitis (GPA) is a small vessel vasculitis characterized by lung and kidney involvement. It is typically a disease of white females and has a poor prognosis with the average life expectancy of 5 months for a patient without treatment. Oral and skin ulcers are considered to be rare presentations.Case: A 39-year-old black male presented to the hospital with oral and skin ulcers and was diagnosed with GPA based on the biopsies of both cutaneous lesions and kidney. He was started on rituximab with minimal improvement. Later he was admitted to the ICU and had plasmapheresis, and he gradually improved and was discharged home 8 days after admission.Conclusion: GPA is an aggressive vascular disorder resulting in possible organ system damage and failure. The role of the sickle cell trait in this patient is undefined, but this combination of gender, race, and presenting symptoms in GPA is extremely unusual.","PeriodicalId":9627,"journal":{"name":"Case Reports in Medicine","volume":null,"pages":null},"PeriodicalIF":0.8000,"publicationDate":"2022-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9453098/pdf/","citationCount":"1","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Case Reports in Medicine","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1155/2022/2737242","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2022/1/1 0:00:00","PubModel":"eCollection","JCR":"Q3","JCRName":"MEDICINE, GENERAL & INTERNAL","Score":null,"Total":0}

引用次数: 1

Abstract

Background: Granulomatosis with polyangiitis (GPA) is a small vessel vasculitis characterized by lung and kidney involvement. It is typically a disease of white females and has a poor prognosis with the average life expectancy of 5 months for a patient without treatment. Oral and skin ulcers are considered to be rare presentations.

Case: A 39-year-old black male presented to the hospital with oral and skin ulcers and was diagnosed with GPA based on the biopsies of both cutaneous lesions and kidney. He was started on rituximab with minimal improvement. Later he was admitted to the ICU and had plasmapheresis, and he gradually improved and was discharged home 8 days after admission.

Conclusion: GPA is an aggressive vascular disorder resulting in possible organ system damage and failure. The role of the sickle cell trait in this patient is undefined, but this combination of gender, race, and presenting symptoms in GPA is extremely unusual.

Abstract Image

查看原文本刊更多论文

口腔和下肢溃疡是肉芽肿病合并多血管炎的最初表现。

背景:肉芽肿病合并多血管炎(GPA)是一种以累及肺和肾脏为特征的小血管炎。它是白人女性的典型疾病，预后较差，未经治疗的患者平均预期寿命为5个月。口腔和皮肤溃疡被认为是罕见的表现。病例:一名39岁黑人男性因口腔和皮肤溃疡就诊，根据皮肤病变和肾脏活检诊断为GPA。他开始服用利妥昔单抗，但收效甚微。后入ICU行血浆置换，病情逐渐好转，入院8天后出院。结论:GPA是一种侵袭性血管疾病，可导致器官系统损伤和衰竭。镰状细胞特征在该患者中的作用尚不明确，但性别、种族和GPA表现症状的结合是极不寻常的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Case Reports in Medicine MEDICINE, GENERAL & INTERNAL-

CiteScore

1.70

自引率

0.00%

发文量

审稿时长

13 weeks