Rabies in South Asia: fighting for elimination.

Q3 Medicine
Fazle-Rabbi Chowdhury, Ariful Basher, Mohammad R Amin, Nazia Hassan, Mohammad I Patwary
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引用次数: 17

Abstract

South Asia is regarded as the hot spot for the tourist and travelers. Unfortunately, three big countries (India, Pakistan and Bangladesh) of this region belong to top five rabies endemic countries of the world. Around 55,000 people die of rabies every year globally and 45% of them belong to South and South East Asia. Countries are now working on the elimination of rabies by the year 2020. Elimination of animal rabies is the pivotal of controlling human rabies. Dog (primary source) registration, population control and mass vaccination are the different ways of eliminating animal rabies. Pre (for risk groups including travelers) and post-exposure vaccine is the core for controlling human rabies. Post-exposure vaccine consists of nerve tissue vaccine and tissue culture vaccine. Due to low antigenicity and post-vaccine neurological complications all countries of South Asia except Pakistan have phased out the production and use of nerve tissue vaccine. To reduce the cost intramuscular regimen is now largely replaced by intradermal regimen and equine rabies immunoglobulin will probably replace human immunoglobulin in future for category III animal bite. 'SAARC' took initiatives for rabies elimination through 'SAARC development fund' which would hopefully play a vital role in regional collaboration to make the region rabies free.

南亚狂犬病:为消除而战。
南亚被认为是旅游和旅行者的热点。不幸的是,该地区的三个大国(印度、巴基斯坦和孟加拉国)属于世界五大狂犬病流行国家。全球每年约有5.5万人死于狂犬病,其中45%发生在南亚和东南亚。各国目前正在努力到2020年消除狂犬病。消灭动物狂犬病是控制人类狂犬病的关键。犬(主要来源)登记、人口控制和大规模疫苗接种是消除动物狂犬病的不同方法。暴露前(针对包括旅行者在内的危险群体)和暴露后疫苗是控制人类狂犬病的核心。暴露后疫苗包括神经组织疫苗和组织培养疫苗。由于抗原性低和疫苗后神经系统并发症,除巴基斯坦外,所有南亚国家都已逐步停止生产和使用神经组织疫苗。为了降低成本,肌内注射疗法现在已被皮内注射疗法所取代,马狂犬病免疫球蛋白将来可能会取代人类免疫球蛋白用于III类动物咬伤。“南盟”通过“南盟发展基金”采取了消除狂犬病的举措,该基金有望在区域合作中发挥重要作用,使该地区无狂犬病。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Recent patents on anti-infective drug discovery
Recent patents on anti-infective drug discovery Medicine-Pharmacology (medical)
CiteScore
2.40
自引率
0.00%
发文量
1
期刊介绍: Recent Patents on Anti-Infective Drug Discovery publishes review articles on recent patents in the field of anti-infective drug discovery e.g. novel bioactive compounds, analogs & targets. A selection of important and recent patents on anti-infective drug discovery is also included in the journal. The journal is essential reading for all researchers involved in anti-infective drug design and discovery.
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