Combined first-trimester screening in northern Finland: experiences of the first ten years.

Clinical Medicine Insights-Reproductive Health Pub Date : 2014-07-30 eCollection Date: 2014-01-01 DOI:10.4137/CMRH.S14958

Anna Merilainen, Sini Peuhkurinen, Timppa Honkasalo, Paivi Laitinen, Hannaleena Kokkonen, Markku Ryynanen, Jaana Marttala

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引用次数: 5

Abstract

Objective: To evaluate the efficacy of first trimester combined screening for Down's syndrome in Northern Finland during the first 10 years of practice.

Methods: During 1 January 2002 to 31 December 2011, 47,896 women participated voluntarily in combined screening during first trimester. The risk cutoff was 1:250. The study period was divided into two time periods; 2002-2006 and 2007-2011.

Results: During the first half of the study period, the detection rate (DR) was 77.3% with a 4.9% false-positive rate (FPR). During the latter half, the DR was 77.1% with a 2.8% FPR.

Conclusions: An important issue is the number of invasive procedures needed to detect one case of Down's syndrome. The screening performance improved markedly in the latter five years period since the FPR lowered from 4.9% to 2.8% and the number of invasive procedures needed to detect one case of Down's syndrome lowered from 15 to 11.

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芬兰北部的联合孕早期筛查:前十年的经验。

目的:评价芬兰北部地区前10年妊娠早期联合筛查唐氏综合征的效果。方法:2002年1月1日至2011年12月31日期间，47,896名妇女自愿参加了妊娠早期联合筛查。风险临界值是1:250。研究阶段分为两个时间段;2002-2006年和2007-2011年。结果:前半期的检出率(DR)为77.3%，假阳性率(FPR)为4.9%。在后半期，DR为77.1%，FPR为2.8%。结论:一个重要的问题是需要多少侵入性手术才能发现一例唐氏综合征。在之后的五年里，筛查效果显著提高，因为FPR从4.9%降至2.8%，检测一例唐氏综合症所需的侵入性手术次数从15次降至11次。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical Medicine Insights-Reproductive Health OBSTETRICS & GYNECOLOGY-

自引率

0.00%

发文量

审稿时长

8 weeks

期刊介绍： Clinical Medicine Insights: Reproductive Health is a peer reviewed; open access journal, which covers all aspects of Reproduction: Gynecology, Obstetrics, and Infertility, spanning both male and female issues, from the physical to the psychological and the social, including: sex, contraception, pregnancy, childbirth, and related topics such as social and emotional impacts. It welcomes original research and review articles from across the health sciences. Clinical subjects include fertility and sterility, infertility and assisted reproduction, IVF, fertility preservation despite gonadotoxic chemo- and/or radiotherapy, pregnancy problems, PPD, infections and disease, surgery, diagnosis, menopause, HRT, pelvic floor problems, reproductive cancers and environmental impacts on reproduction, although this list is by no means exhaustive Subjects covered include, but are not limited to: • fertility and sterility, • infertility and ART, • ART/IVF, • fertility preservation despite gonadotoxic chemo- and/or radiotherapy, • pregnancy problems, • Postpartum depression • Infections and disease, • Gyn/Ob surgery, • diagnosis, • Contraception • Premenstrual tension • Gynecologic Oncology • reproductive cancers • environmental impacts on reproduction, • Obstetrics/Gynaecology • Women''s Health • menopause, • HRT, • pelvic floor problems, • Paediatric and adolescent gynaecology • PID