{"title":"A 2D graphical representation of the sequences of DNA based on triplets and its application.","authors":"Sai Zou, Lei Wang, Junfeng Wang","doi":"10.1186/1687-4153-2014-1","DOIUrl":null,"url":null,"abstract":"<p><p>In this paper, we first present a new concept of 'weight' for 64 triplets and define a different weight for each kind of triplet. Then, we give a novel 2D graphical representation for DNA sequences, which can transform a DNA sequence into a plot set to facilitate quantitative comparisons of DNA sequences. Thereafter, associating with a newly designed measure of similarity, we introduce a novel approach to make similarities/dissimilarities analysis of DNA sequences. Finally, the applications in similarities/dissimilarities analysis of the complete coding sequences of β-globin genes of 11 species illustrate the utilities of our newly proposed method. </p>","PeriodicalId":72957,"journal":{"name":"EURASIP journal on bioinformatics & systems biology","volume":"2014 1","pages":"1"},"PeriodicalIF":0.0000,"publicationDate":"2014-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3896961/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"EURASIP journal on bioinformatics & systems biology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1186/1687-4153-2014-1","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
In this paper, we first present a new concept of 'weight' for 64 triplets and define a different weight for each kind of triplet. Then, we give a novel 2D graphical representation for DNA sequences, which can transform a DNA sequence into a plot set to facilitate quantitative comparisons of DNA sequences. Thereafter, associating with a newly designed measure of similarity, we introduce a novel approach to make similarities/dissimilarities analysis of DNA sequences. Finally, the applications in similarities/dissimilarities analysis of the complete coding sequences of β-globin genes of 11 species illustrate the utilities of our newly proposed method.
在本文中，我们首先为 64 个三连串提出了一个新的 "权重 "概念，并为每种三连串定义了不同的权重。然后，我们给出了一种新颖的 DNA 序列二维图形表示法，它可以将 DNA 序列转化为图集，便于对 DNA 序列进行定量比较。之后，结合新设计的相似度量，我们介绍了一种对 DNA 序列进行相似性/不相似性分析的新方法。最后，在对 11 个物种的β-球蛋白基因的完整编码序列进行相似性/不相似性分析时的应用说明了我们新提出的方法的实用性。
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