Far upstream element-binding protein 1 (FUBP1) is overexpressed in human gastric cancer tissue compared to non-cancerous tissue.

IF 0.3 4区医学 Q4 Medicine

Onkologie Pub Date : 2013-01-01 Epub Date: 2013-10-14 DOI:10.1159/000355659

Fucheng Zhang, Qin Tian, Yaojun Wang

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引用次数: 22

Abstract

Background: The aim of this study was to investigate the role of far upstream element-binding protein 1 (FUBP1) in gastric cancer development.

Patients and methods: Using immunohistochemistry, we detected FUBP1 expression in 18 chronic superficial gastritis patients, 33 chronic atrophic gastritis patients, 21 moderate and severe gastric dysplasia patients, and 31 gastric cancer patients. FUBP1 mRNA expression in gastric cancer tissue and paraneoplastic tissue was measured with fluorescent quantitative reverse transcription polymerase chain reaction.

Results: The FUBP1 expression rates in the chronic atrophic gastritis, moderate and severe dysplasia, and gastric cancer patients were 51.51% (17/33), 76.19% (16/21), and 90.32% (28/31), respectively; these were higher than the expression rate of the chronic superficial gastritis patients (11.11%, 2/18). FUBP1 expression in the gastric cancer patients was significantly higher than that in the chronic atrophic gastritis patients. The relative amount (0.2593 ± 0.1209) of FUBP1 mRNA in the gastric cancer tissue was higher than that in paraneoplastic tissue (0.1969 ± 0.0211) (p < 0.05). There was a statistically significant correlation between overall survival rates and age, sex, lymph node metastasis, and distant metastasis (p < 0.05).

Conclusion: FUBP1 expression differs among gastric tissues. There is a correlation between overall survival rates and age, sex, lymph node metastasis, and distant metastasis.

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远上游元件结合蛋白1 (FUBP1)在人胃癌组织中与非癌组织相比过表达。

背景:本研究旨在探讨远上游元件结合蛋白1 (FUBP1)在胃癌发生发展中的作用。患者及方法:应用免疫组化技术检测18例慢性浅表性胃炎、33例慢性萎缩性胃炎、21例中重度胃发育不良、31例胃癌患者中FUBP1的表达。荧光定量逆转录聚合酶链反应检测胃癌组织和副肿瘤组织中FUBP1 mRNA的表达。结果:FUBP1在慢性萎缩性胃炎、中重度非典型增生和胃癌患者中的表达率分别为51.51%(17/33)、76.19%(16/21)和90.32% (28/31);其表达率高于慢性浅表性胃炎患者(11.11%，2/18)。胃癌患者中FUBP1的表达明显高于慢性萎缩性胃炎患者。胃癌组织中FUBP1 mRNA的相对表达量(0.2593±0.1209)高于副肿瘤组织(0.1969±0.0211)(p < 0.05)。总生存率与年龄、性别、淋巴结转移及远处转移有统计学意义(p < 0.05)。结论:FUBP1在胃组织中的表达存在差异。总生存率与年龄、性别、淋巴结转移和远处转移有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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