{"title":"Ethnopsychopharmacology and pharmacogenomics.","authors":"Hernán Silva","doi":"10.1159/000348741","DOIUrl":null,"url":null,"abstract":"<p><p>Significant differences in response to psychotropic drugs are observed in various ethnic and cultural groups. Ethnopsychiatry is the study of how culture and genetic differences in human groups determine and influence the response to psychotropic agents. Meanwhile, pharmacogenomics studies the influence of genetic variations in the response of patients to different drugs. Pharmacogenetic tests are used to predict drug response and the potential for adverse effects. There are important genetic variations that influence the metabolism and action of psychotropic drugs in different ethnic groups. As examples, the frequencies of CYP2D6 polymorphisms and of the long and short alleles of the promoter region of the serotonin transporter are analyzed. Studies found significant differences in the frequency of polymorphisms of both genes in different countries and ethnic groups. On the basis of this review, the importance of considering ethnic and cultural factors in the prescription of drugs and in the need of further pharmacogenetic studies in different countries and geographical regions is reaffirmed. </p>","PeriodicalId":50851,"journal":{"name":"Advances in Psychosomatic Medicine","volume":"33 ","pages":"88-96"},"PeriodicalIF":0.0000,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000348741","citationCount":"15","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Advances in Psychosomatic Medicine","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1159/000348741","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2013/6/25 0:00:00","PubModel":"Epub","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 15
Abstract
Significant differences in response to psychotropic drugs are observed in various ethnic and cultural groups. Ethnopsychiatry is the study of how culture and genetic differences in human groups determine and influence the response to psychotropic agents. Meanwhile, pharmacogenomics studies the influence of genetic variations in the response of patients to different drugs. Pharmacogenetic tests are used to predict drug response and the potential for adverse effects. There are important genetic variations that influence the metabolism and action of psychotropic drugs in different ethnic groups. As examples, the frequencies of CYP2D6 polymorphisms and of the long and short alleles of the promoter region of the serotonin transporter are analyzed. Studies found significant differences in the frequency of polymorphisms of both genes in different countries and ethnic groups. On the basis of this review, the importance of considering ethnic and cultural factors in the prescription of drugs and in the need of further pharmacogenetic studies in different countries and geographical regions is reaffirmed.
期刊介绍：
The importance of psychosomatic research has been greatly reinforced by evidence demonstrating that psychological phenomena may have distinct effects on human health. Recognizing the complexity of interactions between personality and physical illness, this series employs an interdisciplinary strategy to explore areas where knowledge from psychosomatic medicine may aid in the prevention of specific diseases or help meet the emotional demands of hospitalized patients. In each work, the editor has managed to bring together distinguished contributors, creating a series of coherent and comprehensive reviews on a variety of novel topics.
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