Iliana Valdés Hernández, C Ernesto Montoro Cardoso, Rogelio Hernández-Pando
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引用次数: 0
Abstract
Introduction: development of new antituberculosis vaccines requires the characterization of the cell-mediated immune responses induced by mycobacterial antigens.
Objective: to determine the immunogenic potential of 'Mycobacterium habana' TMC-5135 when using subcutaneous vaccine in Balb/c mice.
Methods: in this study, Balb/c mice were inoculated subcutaneously with live 'Mycobacterium habana' TMC-5135. The production of IFN gamma in cell suspensions obtained from the lungs, the spleen and the lymph nodes after stimulation with mycobacterial antigens Ag85b or culture filtrate antigens (CFA) was recorded.
Results: the production of IFN gamma after stimulation with CFA and Ag85b was higher in mice vaccinated with 'M. habana' than in animals immunized with BCG.
Conclusions: these results encourage new research on 'M. habana' as vaccinal candidate against tuberculosis.
期刊介绍：
La Revista Cubana de Medicina Tropical tiene la misión de publicar artículos científicos especializados en medicina tropical, microbiología, parasitología, epidemiología y otras especialidades afines. Se distribuye directamente por el editor a los suscriptores en formato impreso (ISSN 0375-0760). Está dirigida a profesionales y técnicos en el campo de la medicina tropical, microbiología, parasitología y epidemiología. Recibe contribuciones en idioma español, inglés y portugués sin distinción en el país de procedencia.
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