Comparison of a rapid commercial test, Enterocheck WB(®), with automated blood culture for diagnosis of typhoid fever.

Annals of Tropical Paediatrics Pub Date : 2011-01-01 DOI:10.1179/1465328111Y.0000000030

R Anusha, R Ganesh, J Lalitha

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引用次数: 15

Abstract

Background: Rapid diagnosis of typhoid fever is very important in the timely initiation of therapy.

Objectives: To evaluate the sensitivity and specificity of the Enterocheck WB(®) test.

Methods: In a prospective study, the sensitivity and specificity of Enterocheck WB(®) that detects IgM antibodies to Salmonella typhi were compared with blood culture using BacT/Alert.

Results: Four hundred and fifty patients with suspected typhoid fever were assessed both by blood culture and Enterocheck WB(®); 100 of them were either Enterocheck WB(®)-positive or blood culture-positive or both for S. typhi. Both tests were positive in 47 of the 100 patients. In 45 patients, Enterocheck WB(®) was positive but blood culture was negative. In eight cases, Enterocheck was negative but blood culture was positive. Using blood culture as the gold standard, the sensitivity of Enterocheck WB(®) was 85.5%, specificity 88.6%, negative predictive value 97.7% and positive predictive value 51.1%.

Conclusion: The Enterocheck WB(®) test can be performed at the bedside in 15 minutes and is a useful rapid method for diagnosis of typhoid fever.

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快速商业测试Enterocheck WB(®)与自动血液培养用于伤寒诊断的比较

背景:快速诊断伤寒对及时开始治疗非常重要。目的:评价Enterocheck WB(®)试验的敏感性和特异性。方法:在一项前瞻性研究中，采用BacT/Alert方法比较检测伤寒沙门菌IgM抗体的Enterocheck WB(®)与血培养的敏感性和特异性。结果:对450例疑似伤寒患者进行血培养和Enterocheck WB(®)检测;其中100例伤寒沙门氏菌Enterocheck WB(®)阳性或血培养阳性或两者均阳性。100名患者中有47人两项检测均呈阳性。在45例患者中，Enterocheck WB(®)阳性，但血培养阴性。其中8例肠检查呈阴性，但血培养呈阳性。以血培养为金标准，Enterocheck WB(®)的敏感性为85.5%，特异性为88.6%，阴性预测值为97.7%，阳性预测值为51.1%。结论:Enterocheck WB(®)试验可在床边15分钟内完成，是一种有效的快速诊断伤寒的方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Annals of Tropical Paediatrics 医学-热带医学

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审稿时长

>12 weeks