Marco Matteo Ciccone, Vito Miniello, Roberto Marchioli, Pietro Scicchitano, Francesca Cortese, Vincenzo Palumbo, Stefano Giuseppe Primitivo, Marco Sassara, Gabriella Ricci, Santa Carbonara, Michele Gesualdo, Lucia Diaferio, Giuseppe Mercuro, Giovanni De Pergola, Paola Giordano, Stefano Favale
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引用次数: 48
Abstract
Background: To investigate endothelial dysfunction and morphological vascular changes in childhood obesity.
Methods: 93 overweight/obese children (body mass index 26 ± 5 kg/m(2); median 26 kg/m(2); interquartile range 22-28 kg/m(2)), mean age 10.9 ± 2.7 years, underwent a check-up of total, high-density lipoprotein- and low-density lipoprotein-cholesterol, triglycerides, C-reactive protein, erythrocyte sedimentation rate, and white blood cell count, together with ultrasound measures of flow-mediated dilatation, carotid intima-media thickness, and anterior-posterior diameter of the abdominal aorta.
Results: The body mass index of overweight/obese children had a statistically significant linear relationship (p < 0.05) with triglycerides, erythrocyte sedimentation rate, carotid intima-media thickness, anterior-posterior diameter of the abdominal aorta, and flow-mediated dilatation values.
Conclusions: Overweight/obese children have an initial endothelial dysfunction and vascular damage, i.e., the first stage in the development of atherosclerosis.
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