Hypothyroidism in Noninterferon Treated-HCV Infected Individuals Is Associated with Abnormalities in the Regulation of Th17 Cells.

Hepatitis research and treatment Pub Date : 2010-01-01 Epub Date: 2010-03-08 DOI:10.1155/2010/971095

Luis A Salazar, Xóchitl Garcia-Samper, Rafael Suarez-Carpio, María C Jimenez-Martínez, Erika P Rendón-Huerta, Felipe A Masso, Teresa I Fortoul, Luis F Montaño

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引用次数: 6

Abstract

HCV-Ag-specific TH17 cells secrete IL17, a cytokine involved in autoimmune diseases and regulated by IL10 and TGF-b. 5-12% of patients with chronic HCV infection have hypothyroidism. We evaluated the role of these cytokines in this patients by determining serum concentration of TsH, T3, free T4, IL2, IL10, IL12, IL17, TGF-b, anti-TG, TPO, CCP, GBM, and cardiolipin antibodies in 87 chronically noninterferon treated HCV-infected patients. 20 patients (group A) had elevated TsH values (>5 μUI/ml) whereas the remaining 67 (group B) had normal values. The percentage of anti-TPO, TG, GBM, and cardiolipin antibodies in group A patients (33%, 41%, 5% and 5%, resp.) as well as IL17, IL2 and TGF-b concentrations (25 ± 23 pg/ml, 643 ± 572 pg/ml, and 618 ± 221 pg/ml, resp.) were significantly higher than group B. Abnormal Th17 regulation mediated by IL-2 and low TGF-b concentrations is associated with hypothyroidism in chronically-infected HCV patients.

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非干扰素治疗的hcv感染个体甲状腺功能减退与Th17细胞调节异常相关

hcv - ag特异性TH17细胞分泌IL17，这是一种参与自身免疫性疾病并受IL10和TGF-b调节的细胞因子。5-12%的慢性HCV感染患者有甲状腺功能减退。我们通过测定87例慢性非干扰素治疗的hcv感染患者血清TsH、T3、游离T4、IL2、IL10、IL12、IL17、TGF-b、抗tg、TPO、CCP、GBM和心磷脂抗体的浓度来评估这些细胞因子在该患者中的作用。A组20例TsH值升高(>5 μUI/ml)， B组67例TsH值正常。A组患者抗tpo、TG、GBM和心磷脂抗体百分比(33%、41%、5%和5%，分别高于b组)，IL-2、IL-2和TGF-b浓度(25±23 pg/ml、643±572 pg/ml和618±221 pg/ml，分别高于b组。IL-2介导的Th17异常调节和TGF-b低浓度与慢性HCV感染患者甲状腺功能减退有关。

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Hepatitis research and treatment

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