Directed stem cell differentiation: the role of physical forces.

Q2 Biochemistry, Genetics and Molecular Biology

Cell Communication and Adhesion Pub Date : 2010-04-01 DOI:10.3109/15419061.2010.492535

Kelly C Clause, Li J Liu, Kimimasa Tobita

引用次数: 78

Abstract

A number of factors contribute to the control of stem cell fate. In particular, the evidence for how physical forces control the stem cell differentiation program is now accruing. In this review, the authors discuss the types of physical forces: mechanical forces, cell shape, extracellular matrix geometry/properties, and cell-cell contacts and morphogenic factors, which evidence suggests play a role in influencing stem cell fate.

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定向干细胞分化:物理力量的作用。

许多因素有助于控制干细胞的命运。特别是，关于物理力量如何控制干细胞分化程序的证据正在积累。在这篇综述中，作者讨论了物理力的类型:机械力、细胞形状、细胞外基质几何/性质、细胞-细胞接触和形态发生因素，证据表明这些因素在影响干细胞的命运中发挥作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cell Communication and Adhesion 生物-生化与分子生物学

CiteScore

2.50

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Cessation Cell Communication and Adhesion is an international Open Access journal which provides a central forum for research on mechanisms underlying cellular signalling and adhesion. The journal provides a single source of information concerning all forms of cellular communication, cell junctions, adhesion molecules and families of receptors from diverse biological systems. The journal welcomes submission of original research articles, reviews, short communications and conference reports.