[Meta-analysis on serological effect of the primary vaccination for Japanese encephalitis of the literatures].

中国疫苗和免疫 Pub Date : 2009-12-01

Zun-dong Yin, Hui-ming Luo, Yi-xing Li

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Abstract

Objectives: To summary and compare the different seroconversion rates after the primary vaccination for the Japanese encephalitis (JE), and to evaluate the serological effect of 3 kinds of JE vaccines.

Method: Searching "CHKD", "Wanfang" database and "EMCC" databases, the studies of the immunogenicity after the primary JEV vaccination, all randomized controlled trials or non-randomized controlled trials were included, and statistical analysis were made by RevMan 4.2.10 software.

Results: A total of 12 literatures were included, 7 studies had control groups. The seroconversion rates after the primary vaccination, JEV-L, JEV-I (Vero) and JEV-I (PHK), were 86% (95% CI: 80%-91%), 83% (95% CI: 72% -94%) and 64% (95% CI: 58%-69%) respectively. Comparing the seroconversion rates of the 3 kinds of vaccines after primary immunization, the rate of JEV-I (Vero) was significantly higher than the rate of JEV-I (PHK), other comparisons were no significant difference.

Conclusion: The serological effects of JEV-L and JEV-I (Vero) after the primary vaccination were higher than that of JEV-I (PHK).

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[文献一次接种对乙型脑炎血清学影响的meta分析]。

目的:总结比较乙脑初次接种后血清转换率的差异，评价3种乙脑疫苗的血清学效果。方法:检索“CHKD”、“万方”数据库和“EMCC”数据库，纳入乙脑初次接种后的免疫原性研究，包括所有随机对照试验和非随机对照试验，采用RevMan 4.2.10软件进行统计分析。结果:共纳入12篇文献，其中7篇为对照组。初次接种后，JEV-L、jev - 1 (Vero)和jev - 1 (PHK)的血清转化率分别为86% (95% CI: 80% ~ 91%)、83% (95% CI: 72% ~ 94%)和64% (95% CI: 58% ~ 69%)。比较3种疫苗一次免疫后的血清转换率，jev - 1 (Vero)的转换率显著高于jev - 1 (PHK)的转换率，其他比较差异无统计学意义。结论:JEV-L和jev - 1 (Vero)初次接种后的血清学效果高于jev - 1 (PHK)。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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中国疫苗和免疫

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