Strategies to extend plasma half-lives of recombinant antibodies.

IF 6.9 2区 医学 Q1 IMMUNOLOGY
Roland E Kontermann
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引用次数: 200

Abstract

Recombinant antibodies, including whole antibodies, antibody fragments, antibody fusion proteins or conjugates, and more recently also small antibody mimetics, have found increasing applications as therapeutics, e.g. for the treatment of cancer or inflammatory diseases. While whole antibodies have an exceptionally long half-life, small antibody derivatives often suffer from rapid elimination from the circulation. In order to improve administration and therapeutic efficacy, modifications to extend the plasma half-life have been developed and implemented in these antibody formats. This review provides a comprehensive summary of the various strategies currently available to extend plasma half-lives of recombinant antibodies.

延长重组抗体血浆半衰期的策略。
重组抗体,包括全抗体、抗体片段、抗体融合蛋白或偶联物,以及最近的小抗体模拟物,作为治疗手段的应用越来越广泛,例如用于治疗癌症或炎症性疾病。虽然全抗体的半衰期特别长,但小抗体衍生物往往会从循环中迅速消除。为了改善给药和治疗效果,已经在这些抗体格式中开发和实施了延长血浆半衰期的修改。本文综述了目前可用于延长重组抗体血浆半衰期的各种策略。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
BioDrugs
BioDrugs 医学-免疫学
CiteScore
12.60
自引率
2.90%
发文量
50
审稿时长
>12 weeks
期刊介绍: An essential resource for R&D professionals and clinicians with an interest in biologic therapies. BioDrugs covers the development and therapeutic application of biotechnology-based pharmaceuticals and diagnostic products for the treatment of human disease. BioDrugs offers a range of additional enhanced features designed to increase the visibility, readership and educational value of the journal’s content. Each article is accompanied by a Key Points summary, giving a time-efficient overview of the content to a wide readership. Articles may be accompanied by plain language summaries to assist patients, caregivers and others in understanding important medical advances. The journal also provides the option to include various other types of enhanced features including slide sets, videos and animations. All enhanced features are peer reviewed to the same high standard as the article itself. Peer review is conducted using Editorial Manager®, supported by a database of international experts. This database is shared with other Adis journals.
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