{"title":"Chemogenomics strategies for G-protein coupled receptor hit finding.","authors":"W Guba","doi":"10.1007/978-3-540-37635-4_2","DOIUrl":null,"url":null,"abstract":"<p><p>Targeting protein superfamilies via chemogenomics is based on a similarity clustering of gene sequences and molecular structures of ligands. Both target and ligand clusters are linked by generating binding affinity profiles of chemotypes vs a target panel. The application of this multidimensional similarity paradigm will be described in the context of Lead Generation to identify novel chemical hit classes for G-protein coupled receptors.</p>","PeriodicalId":80277,"journal":{"name":"Ernst Schering Research Foundation workshop","volume":" 58","pages":"21-9"},"PeriodicalIF":0.0000,"publicationDate":"2006-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"3","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Ernst Schering Research Foundation workshop","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1007/978-3-540-37635-4_2","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 3
Abstract
Targeting protein superfamilies via chemogenomics is based on a similarity clustering of gene sequences and molecular structures of ligands. Both target and ligand clusters are linked by generating binding affinity profiles of chemotypes vs a target panel. The application of this multidimensional similarity paradigm will be described in the context of Lead Generation to identify novel chemical hit classes for G-protein coupled receptors.
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