F. Zentz , R. Labia , D. Sirot , O. Faure , R. Grillot , A. Valla
{"title":"Syntheses, in vitro antibacterial and antifungal activities of a series of N-alkyl, 1,4-dithiines","authors":"F. Zentz , R. Labia , D. Sirot , O. Faure , R. Grillot , A. Valla","doi":"10.1016/j.farmac.2005.06.015","DOIUrl":null,"url":null,"abstract":"<div><p>A series of dithiines were synthesized by cyclization of 4-(alkylamino)-4-oxobutanoic acids under the action of SOCl<sub>2</sub>. Their in vitro antibacterial and antifungal activities have been evaluated against reference strains and versus reference compounds. The so-called ‘isoimides’ <strong>2a</strong>, <strong>2b</strong><span><span> were totally inactive whereas some imides had low </span>MICs for few bacteria and for few fungal microorganisms.</span></p></div>","PeriodicalId":77128,"journal":{"name":"Farmaco (Societa chimica italiana : 1989)","volume":"60 11","pages":"Pages 944-947"},"PeriodicalIF":0.0000,"publicationDate":"2005-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.farmac.2005.06.015","citationCount":"21","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Farmaco (Societa chimica italiana : 1989)","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0014827X05001503","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 21
Abstract
A series of dithiines were synthesized by cyclization of 4-(alkylamino)-4-oxobutanoic acids under the action of SOCl2. Their in vitro antibacterial and antifungal activities have been evaluated against reference strains and versus reference compounds. The so-called ‘isoimides’ 2a, 2b were totally inactive whereas some imides had low MICs for few bacteria and for few fungal microorganisms.