[Effects of lactone I from Atractylodes macrocephala Koidz on cytokines and proteolysis-inducing factors in cachectic cancer patients].

Di 1 jun yi da xue xue bao = Academic journal of the first medical college of PLA Pub Date : 2005-10-01

Yi Liu, Feng Ye, Gen-quan Qiu, Mei Zhang, Rui Wang, Qun-ying He, Yun Cai

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Abstract

Objective: To observe the effect of lactone I from Atractylodes macrocephala Koidz (LAMK I) on the cytokines and proteolysis-inducing factors (PIF) in cachectic cancer patients.

Method: Sixty-four cachectic cancer patients were randomized into two groups, namely LAMK I group and FOE (fish oil-enriched nutritional supplementation) treatment group. The appetite, body weight changes, mid-arm muscle circumference (MAMC), and KPS scores were recorded 3 and 7 weeks after the treatment. Immunohistochemistry was used to analyze the changes in the cytokines interleukin (IL)-1, IL-6 and tumor necrosis factor (TNF)-alpha and Western blotting employed to examine the changes of PIF after the treatment.

Results: The patients' appetite and MAMC in LAMKI group was better than those of patients in FOE group, and the serum IL-1 and TNF-alpha levels and urine PIF level were significantly lower than those of FOE group. Body weight and serum IL-6 level were not significantly different between the two groups.

Conclusion: Lactone I from Atractylodes macrocephala Koidz can be beneficial for treating cancer cachexia.

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[苍术内酯I对恶病质癌患者细胞因子及蛋白水解诱导因子的影响]。

目的:观察白术内酯I (LAMK I)对恶病质癌患者细胞因子及蛋白水解诱导因子(PIF)的影响。方法:64例恶病质癌患者随机分为两组，分别为LAMK I组和富鱼油营养补充剂治疗组。治疗后3、7周分别记录两组患者的食欲、体重变化、中臂肌围(MAMC)及KPS评分。免疫组化法分析治疗后细胞因子白介素(IL)-1、IL-6和肿瘤坏死因子(TNF)- α的变化，Western blotting法检测治疗后PIF的变化。结果:LAMKI组患者的食欲、MAMC均优于FOE组，血清IL-1、tnf - α水平及尿PIF水平均显著低于FOE组。两组患者体重、血清IL-6水平差异无统计学意义。结论:苍术内酯可有效治疗恶性肿瘤恶病质。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Di 1 jun yi da xue xue bao = Academic journal of the first medical college of PLA

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