Lipid bilayers: Phase behavior and nanomechanics.

4区 生物学 Q4 Biochemistry, Genetics and Molecular Biology
Current topics in membranes Pub Date : 2020-01-01 Epub Date: 2020-09-16 DOI:10.1016/bs.ctm.2020.08.005
Lorena Redondo-Morata, Patricia Losada-Pérez, Marina Inés Giannotti
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引用次数: 10

Abstract

Lipid membranes are involved in many physiological processes like recognition, signaling, fusion or remodeling of the cell membrane or some of its internal compartments. Within the cell, they are the ultimate barrier, while maintaining the fluidity or flexibility required for a myriad of processes, including membrane protein assembly. The physical properties of in vitro model membranes as model cell membranes have been extensively studied with a variety of techniques, from classical thermodynamics to advanced modern microscopies. Here we review the nanomechanics of solid-supported lipid membranes with a focus in their phase behavior. Relevant information obtained by quartz crystal microbalance with dissipation monitoring (QCM-D) and atomic force microscopy (AFM) as complementary techniques in the nano/mesoscale interface is presented. Membrane morphological and mechanical characterization will be discussed in the framework of its phase behavior, phase transitions and coexistence, in simple and complex models, and upon the presence of cholesterol.

脂质双层:相行为和纳米力学。
脂质膜参与了许多生理过程,如识别、信号传导、融合或重塑细胞膜或其内部部分室室。在细胞内,它们是最终的屏障,同时保持无数过程所需的流动性或灵活性,包括膜蛋白组装。体外模型膜作为模型细胞膜的物理性质已经被广泛地研究了各种技术,从经典热力学到先进的现代显微镜。本文综述了固体支撑脂质膜的纳米力学,重点介绍了它们的相行为。介绍了石英晶体微天平与耗散监测(QCM-D)和原子力显微镜(AFM)作为互补技术在纳米/中尺度界面中获得的相关信息。膜形态和力学表征将在其相行为,相变和共存的框架下进行讨论,在简单和复杂的模型,并在胆固醇的存在。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Current topics in membranes
Current topics in membranes 生物-生化与分子生物学
CiteScore
3.50
自引率
0.00%
发文量
10
审稿时长
>12 weeks
期刊介绍: Current Topics in Membranes provides a systematic, comprehensive, and rigorous approach to specific topics relevant to the study of cellular membranes. Each volume is a guest edited compendium of membrane biology.
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