Roles of phosphatidyl inositol 3 kinase gamma (PI3Kγ) in respiratory diseases.

IF 4.1 Q2 CELL BIOLOGY

Cell Stress Pub Date : 2021-03-08 DOI:10.15698/cst2021.04.246

Valentina Sala, Angela Della Sala, Alessandra Ghigo, Emilio Hirsch

引用次数: 6

Abstract

Phosphatidyl inositol 3 kinase gamma (PI3Kγ) is expressed in all the cell types that are involved in airway inflammation and disease, including not only leukocytes, but also structural cells, where it is expressed at very low levels under physiological conditions, while is significantly upregulated after stress. In the airways, PI3Kγ behaves as a trigger or a controller, depending on the pathological context. In this review, the contribution of PI3Kγ in a plethora of respiratory diseases, spanning from acute lung injury, pulmonary fibrosis, asthma, cystic fibrosis and response to both bacterial and viral pathogens, will be commented.

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磷脂酰肌醇3激酶γ (PI3Kγ)在呼吸系统疾病中的作用

磷脂酰肌醇3激酶γ (PI3Kγ)在参与气道炎症和疾病的所有细胞类型中表达，不仅包括白细胞，还包括结构细胞，在生理条件下表达水平非常低，而在应激后显着上调。在气道中，PI3Kγ作为触发器或控制器，取决于病理环境。在这篇综述中，PI3Kγ在多种呼吸系统疾病中的作用，包括急性肺损伤、肺纤维化、哮喘、囊性纤维化和对细菌和病毒病原体的反应，将被评论。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cell Stress Biochemistry, Genetics and Molecular Biology-Biochemistry, Genetics and Molecular Biology (miscellaneous)

CiteScore

13.50

自引率

0.00%

发文量

审稿时长

15 weeks

期刊介绍： Cell Stress is an open-access, peer-reviewed journal that is dedicated to publishing highly relevant research in the field of cellular pathology. The journal focuses on advancing our understanding of the molecular, mechanistic, phenotypic, and other critical aspects that underpin cellular dysfunction and disease. It specifically aims to foster cell biology research that is applicable to a range of significant human diseases, including neurodegenerative disorders, myopathies, mitochondriopathies, infectious diseases, cancer, and pathological aging. The scope of Cell Stress is broad, welcoming submissions that represent a spectrum of research from fundamental to translational and clinical studies. The journal is a valuable resource for scientists, educators, and policymakers worldwide, as well as for any individual with an interest in cellular pathology. It serves as a platform for the dissemination of research findings that are instrumental in the investigation, classification, diagnosis, and therapeutic management of major diseases. By being open-access, Cell Stress ensures that its content is freely available to a global audience, thereby promoting international scientific collaboration and accelerating the exchange of knowledge within the research community.