Silicon surface assisted laser desorption ionization mass spectrometry for quantitative analysis.

IF 16.4 1区 化学 Q1 CHEMISTRY, MULTIDISCIPLINARY
Accounts of Chemical Research Pub Date : 2021-04-01 Epub Date: 2021-04-04 DOI:10.1177/14690667211006017
Alexander A Grechnikov, Alexey S Borodkov, Yaroslav O Simanovsky, Sergey M Nikiforov
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引用次数: 2

Abstract

The approach to quantitative analysis by silicon Surface Assisted Laser Desorption Ionization Mass Spectrometry (Si-SALDI) is proposed. The approach is based on the new method for forming an active surface layer on a silicon substrate by exposing to laser radiation directly in the ion source of a mass spectrometer. The method can be used repeatedly on the same substrate, providing high reproducibility of its surface ionization properties and high ionization efficiency of organic compounds. Within the proposed approach, the methods of improvement of signal reproducibility are also considered, including continuous monitoring of the silicon surface ionization properties using a Knudsen effusion cell; scanning the surface of a silicon substrate with a laser beam; selecting the optimal value of laser fluence and using a reproducible sample introduction technique. It is demonstrated that this approach can be successfully applied to quantify clinically relevant concentrations of pharmaceutical drugs in extracts of blood.

硅表面辅助激光解吸电离质谱法定量分析。
提出了硅表面辅助激光解吸电离质谱(Si-SALDI)定量分析方法。该方法是基于在质谱计离子源中直接暴露在激光辐射下在硅衬底上形成活性表面层的新方法。该方法可在同一底物上重复使用,其表面电离性质的重现性高,有机化合物的电离效率高。在提出的方法中,还考虑了改善信号再现性的方法,包括使用Knudsen液池连续监测硅表面电离特性;用激光束扫描硅衬底表面;选择激光通量的最佳值并采用可重复样品导入技术。结果表明,该方法可以成功地应用于定量血液提取物中药物的临床相关浓度。
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来源期刊
Accounts of Chemical Research
Accounts of Chemical Research 化学-化学综合
CiteScore
31.40
自引率
1.10%
发文量
312
审稿时长
2 months
期刊介绍: Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.
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