Early Insights into COVID-19 in Persons Living with HIV and Cardiovascular Manifestations.

Jelani K Grant, Louis Vincent, Bertrand Ebner, Barry E Hurwitz, Maria L Alcaide, Claudia Martinez
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引用次数: 1

Abstract

Persons living with HIV-1 (PLHIV) are at increased risk of cardiovascular complications in part due to the persistent inflammatory state despite viral suppression. SARS-CoV-2, the virus causing COVID-19, was declared a pandemic virus in March 2020, and caused over 30 million cases and 900,000 deaths worldwide to date. Individuals with COVID-19 are manifesting acute cardiovascular complications because of the inflammatory response associated with SARS-CoV-2 infection. It is not yet known whether having COVID-19 in the context of ongoing HIV-1 infection results in worse cardiovascular complications than in PLHIV who have not had COVID-19 infection. In this review, the potential for exacerbated cardiovascular manifestations in persons coinfected with HIV-1 and COVID-19 is considered.

艾滋病毒感染者和心血管症状患者的COVID-19早期认识
HIV-1 (PLHIV)感染者发生心血管并发症的风险增加,部分原因是尽管病毒受到抑制,但持续的炎症状态。导致COVID-19的病毒SARS-CoV-2于2020年3月被宣布为大流行病毒,迄今已在全球造成3000多万例病例和90万例死亡。由于与SARS-CoV-2感染相关的炎症反应,COVID-19患者表现出急性心血管并发症。目前尚不清楚在持续感染HIV-1的情况下感染COVID-19是否会比未感染COVID-19的PLHIV更严重的心血管并发症。在这篇综述中,考虑了HIV-1和COVID-19合并感染的人心血管症状加重的可能性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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