The Current State of Oncolytic Herpes Simplex Virus for Glioblastoma Treatment.

IF 6.7
Oncolytic Virotherapy Pub Date : 2021-02-24 eCollection Date: 2021-01-01 DOI:10.2147/OV.S268426
Hong-My Nguyen, Dipongkor Saha
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引用次数: 18

Abstract

Glioblastoma (GBM) is a lethal primary malignant brain tumor with no current effective treatments. The recent emergence of immuno-virotherapy and FDA approval of T-VEC have generated a great expectation towards oncolytic herpes simplex viruses (oHSVs) as a promising treatment option for GBM. Since the generation and testing of the first genetically engineered oHSV in glioma in the early 1990s, oHSV-based therapies have shown a long way of great progress in terms of anti-GBM efficacy and safety, both preclinically and clinically. Here, we revisit the literature to understand the recent advancement of oHSV in the treatment of GBM. In addition, we discuss current obstacles to oHSV-based therapies and possible strategies to overcome these pitfalls.

Abstract Image

Abstract Image

Abstract Image

溶瘤性单纯疱疹病毒治疗胶质母细胞瘤的现状。
胶质母细胞瘤(GBM)是一种致命的原发性恶性脑肿瘤,目前尚无有效的治疗方法。最近出现的免疫病毒疗法和FDA批准的T-VEC使人们对溶瘤性单纯疱疹病毒(oHSVs)作为GBM的一种有希望的治疗选择产生了很大的期望。自20世纪90年代初在胶质瘤中产生和测试了第一个基因工程oHSV以来,基于oHSV的治疗在抗gbm的有效性和安全性方面取得了长足的进展,无论是临床前还是临床。在这里,我们重温文献,了解oHSV治疗GBM的最新进展。此外,我们还讨论了目前基于ohv的治疗的障碍以及克服这些陷阱的可能策略。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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