Successful treatment of neurocysticercosis with albendazole desensitization.

IF 4.6 Q2 MATERIALS SCIENCE, BIOMATERIALS

ACS Applied Bio Materials Pub Date : 2024-06-01 DOI:10.12932/AP-191020-0983

Anh P Nguyen, Wesley Hoffman, Bennett H Penn, David Pham, Suzanne S Teuber

引用次数: 0

Abstract

Background: Neurocysticercosis is a growing public health problem in the United States. Albendazole is a mainstay of medical therapy for neurocysticercosis, and here we present a case of hypersensitivity to albendazole leading to life-threatening disease progression.

Objective: To report the first successful albendazole desensitization protocol.

Methods: An oral albendazole 12-step desensitization protocol was developed, starting with 0.001 mg and progressing at 15 minutes intervals. Dosage for each subsequent step was as follows: 0.003 mg, 0.01 mg, 0.03 mg, 0.1 mg, 0.3 mg, 1 mg, 3 mg, 10 mg, 30 mg, 100 mg, 300mg.

Results: The patient rapidly improved from a symptomatic standpoint, and repeat MRI showed a dramatic improvement in lesions.

Conclusions: This successful desensitization protocol to albendazole can be of value to other patients with history suggestive of IgE-mediated allergy needing treatment for parasitic infections.

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阿苯达唑脱敏疗法成功治疗了神经囊虫病。

背景：神经囊虫病是美国一个日益严重的公共卫生问题。阿苯达唑是治疗神经囊虫病的主要药物，我们在此介绍一例对阿苯达唑过敏导致疾病恶化危及生命的病例：报告首个成功的阿苯达唑脱敏方案：方法：制定了口服阿苯达唑 12 步脱敏方案，从 0.001 毫克开始，每隔 15 分钟递增一次。随后每个步骤的剂量如下：0.003 毫克、0.01 毫克、0.03 毫克、0.1 毫克、0.3 毫克、1 毫克、3 毫克、10 毫克、30 毫克、100 毫克、300 毫克：患者的症状迅速改善，重复磁共振成像显示病灶显著改善：结论：这一成功的阿苯达唑脱敏方案对其他有 IgE 媒介过敏史并需要治疗寄生虫感染的患者很有价值。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

ACS Applied Bio Materials Chemistry-Chemistry (all)

CiteScore

9.40

自引率

2.10%

发文量

464