{"title":"Measuring butyrylcholinesterase activity and hematological parameters in farmers exposed to pesticides: a case and control study from Morocco.","authors":"H Sine, A Achbani, K Filali","doi":"10.1080/19338244.2021.1886034","DOIUrl":null,"url":null,"abstract":"<p><p>The Farmers are exposed to a wide range of pesticides. The application of these pesticides has been documented to lead to several adverse health effects. This aim of this case-control study was to estimate risks linked to pesticide exposure among farmers in the Souss region of Morocco through the analysis of serum butyrylcholinesterase (BChE) activity and hematological parameters. This prospective study included 98 participants (49 farmers and 49 controls). A questionnaire was used to collect socio-demographic data, technical information regarding the application of pesticides, previous poisonings by pesticides, and training on the use of pesticides. The blood samples were collected for hematological parameters and BChE analysis, and the activity of BChE was measured spectrophotometrically by the butyrlthiocholine method. The results showed no significant differences in hemoglobin (HB), hematocrit, mean corpuscular volume, platelets, red blood cell, and leukocyte cell counts between both the exposed farmer and the control group. In contrast, a significant decreased in mean corpuscular HB, mean corpuscular HB concentration, eosinophils, and basophils counts were observed. In addition, the exposed group showed a significant decrease in the BChE activity (<i>p</i> < .001) compared to the control group. Farmers exposed to pesticides in the Souss Massa region may be at risk of hematological alterations as well as neurotoxicity, characterized by inhibition of BChE enzyme activity.</p>","PeriodicalId":8173,"journal":{"name":"Archives of Environmental & Occupational Health","volume":"77 4","pages":"345-350"},"PeriodicalIF":1.4000,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/19338244.2021.1886034","citationCount":"4","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Archives of Environmental & Occupational Health","FirstCategoryId":"93","ListUrlMain":"https://doi.org/10.1080/19338244.2021.1886034","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2021/2/15 0:00:00","PubModel":"Epub","JCR":"Q4","JCRName":"ENVIRONMENTAL SCIENCES","Score":null,"Total":0}
引用次数: 4
Abstract
The Farmers are exposed to a wide range of pesticides. The application of these pesticides has been documented to lead to several adverse health effects. This aim of this case-control study was to estimate risks linked to pesticide exposure among farmers in the Souss region of Morocco through the analysis of serum butyrylcholinesterase (BChE) activity and hematological parameters. This prospective study included 98 participants (49 farmers and 49 controls). A questionnaire was used to collect socio-demographic data, technical information regarding the application of pesticides, previous poisonings by pesticides, and training on the use of pesticides. The blood samples were collected for hematological parameters and BChE analysis, and the activity of BChE was measured spectrophotometrically by the butyrlthiocholine method. The results showed no significant differences in hemoglobin (HB), hematocrit, mean corpuscular volume, platelets, red blood cell, and leukocyte cell counts between both the exposed farmer and the control group. In contrast, a significant decreased in mean corpuscular HB, mean corpuscular HB concentration, eosinophils, and basophils counts were observed. In addition, the exposed group showed a significant decrease in the BChE activity (p < .001) compared to the control group. Farmers exposed to pesticides in the Souss Massa region may be at risk of hematological alterations as well as neurotoxicity, characterized by inhibition of BChE enzyme activity.
期刊介绍：
Archives of Environmental & Occupational Health , originally founded in 1919 as the Journal of Industrial Hygiene, and perhaps most well-known as the Archives of Environmental Health, reports, integrates, and consolidates the latest research, both nationally and internationally, from fields germane to environmental health, including epidemiology, toxicology, exposure assessment, modeling and biostatistics, risk science and biochemistry. Publishing new research based on the most rigorous methods and discussion to put this work in perspective for public health, public policy, and sustainability, the Archives addresses such topics of current concern as health significance of chemical exposure, toxic waste, new and old energy technologies, industrial processes, and the environmental causation of disease such as neurotoxicity, birth defects, cancer, and chronic degenerative diseases. For more than 90 years, this noted journal has provided objective documentation of the effects of environmental agents on human and, in some cases, animal populations and information of practical importance on which decisions are based.
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