“Determination of domperidone in tablet dosage form by anodic differential pulse voltammetry”

Abstract

A differential pulse voltammetric method was described for the determination of domperidone. The method was based on the anodic oxidation of domperidone on a glassy carbon electrode at +0.64 V vs. SCE in Britton–Robinson buffer solution of pH 2.3. The reversibility of the oxidation was tested by cyclic voltammetry; the electrode process is irreversible and diffusion–adsorption controlled. Calibrations are linear over the range 1.0 × 10^–6–2.0 × 10^–5 M of domperidone with a detection limit of 4.0 × 10^–7 M. The method was applied, without any interference from the excipients, to the determination of the drug in a tablet dosage form.