Manganese superoxide dismutase in pathogenic fungi: An issue with pathophysiological and phylogenetic involvements

FEMS immunology and medical microbiology Pub Date : 2005-09-01 DOI:10.1016/j.femsim.2005.06.003

Emilie Fréalle , Christophe Noël , Eric Viscogliosi , Daniel Camus , Eduardo Dei-Cas , Laurence Delhaes

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引用次数: 46

Abstract

Manganese-containing superoxide dismutases (MnSODs) are ubiquitous metalloenzymes involved in cell defence against endogenous and exogenous reactive oxygen species. In fungi, using this essential enzyme for phylogenetic analysis of Pneumocystis and Ganoderma genera, and of species selected among Ascomycota, Basidiomycota and Zygomycota, provided interesting results in taxonomy and evolution. The role of mitochondrial and cytosolic MnSODs was explored in some pathogenic Basidiomycota yeasts (Cryptococcus neoformans var. grubii, Cryptococcus neoformans var. gattii, Malassezia sympodialis), Ascomycota filamentous fungi (Aspergillus fumigatus), and Ascomycota yeasts (Candida albicans). MnSOD-based phylogenetic and pathogenic data are confronted in order to evaluate the roles of fungal MnSODs in pathophysiological mechanisms.

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致病真菌中的锰超氧化物歧化酶:一个涉及病理生理和系统发育的问题

含锰超氧化物歧化酶(mnsod)是一种普遍存在的金属酶，参与细胞对内源性和外源性活性氧的防御。在真菌中，利用该酶对肺孢子菌属和灵芝属以及子囊菌门、担子菌门和联合菌门中所选择的物种进行系统发育分析，提供了有趣的分类和进化结果。研究了线粒体和细胞质内mnsod在一些致病担子菌酵母(grubii新型隐球菌、ggati新型隐球菌、Malassezia sympodialis)、子囊菌丝状真菌(烟曲霉)和子囊菌酵母(白色念珠菌)中的作用。为了评估真菌mnsod在病理生理机制中的作用，本文对基于mnsod的系统发育和致病数据进行了分析。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

FEMS immunology and medical microbiology 医学-传染病学

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审稿时长

3-8 weeks

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