[Serum soluble CD40L level and its application in coronary heart disease].

Hunan yi ke da xue xue bao = Hunan yike daxue xuebao = Bulletin of Hunan Medical University Pub Date : 2003-12-01

Jiang Li, Dao-quan Peng, Shui-ping Zhao

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Abstract

Objective: To investigate the serum level of soluble CD40 ligand (sCD40L) in coronary heart disease and its relationship with serum lipid levels.

Methods: Enzyme-linked immunosorbent (EIA) was used to measure sCD40L in 129 patients with coronary heart disease (46 with acute myocardial infarction, 37 with unstable angina pectoris and the other 46 with stable angina pectoris) and 30 matched healthy controls.

Results: sCD40L level was significantly higher in patients with acute coronary syndrome (ACS) [(2. 99 +/- 2.19), (2.23 +/- 0.67) ng/ml in acute myocardial infarction and unstable angina pectoris group, respectively] than that of those with stable coronary heart disease and that of controls [(1.12 +/- 0.42) and (0.89 +/- 0.55) ng/ml, respectively] (P < 0.05). Serum sCD40L level was significantly positively related to ApoB100 (r = 0.159, P = 0.046), and negatively related to HDL-C (r = -0.192, P = 0.015).

Conclusion: The levels of sCD40L increase in acute coronary syndrome, which may be related to the pathogenesis of ACS, and can be used as a potential marker of plaque instability.

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[血清可溶性CD40L水平及其在冠心病中的应用]。

目的:探讨冠心病患者血清可溶性CD40配体(sCD40L)水平及其与血脂水平的关系。方法:采用酶联免疫吸附剂(EIA)测定129例冠心病患者(急性心肌梗死46例，不稳定型心绞痛37例，稳定型心绞痛46例)和30例匹配的健康对照者的sCD40L。结果:sCD40L水平在急性冠脉综合征(ACS)患者中明显升高[2]。急性心肌梗死组和不稳定型心绞痛组[分别为(1.12 +/- 0.42)和(0.89 +/- 0.55)ng/ml]、(2.23 +/- 0.67)ng/ml，比稳定型冠心病组和对照组[分别为(1.12 +/- 0.42)和(0.89 +/- 0.55)ng/ml]高(P < 0.05)。血清sCD40L水平与ApoB100呈正相关(r = 0.159, P = 0.046)，与HDL-C呈负相关(r = -0.192, P = 0.015)。结论:sCD40L水平在急性冠脉综合征中升高，可能与ACS的发病机制有关，可作为斑块不稳定的潜在标志。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Hunan yi ke da xue xue bao = Hunan yike daxue xuebao = Bulletin of Hunan Medical University

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