Michael Chich-Kuang Chang, Andrew Ying-Siu Lee, Wen-Ye Lin, Tien-Jen Chen, Miin-Yaw Shyu, Wen-Fung Chang
{"title":"Myocardial and peripheral concentrations of beta-endorphin before and following myocardial ischemia and reperfusion during coronary angioplasty.","authors":"Michael Chich-Kuang Chang, Andrew Ying-Siu Lee, Wen-Ye Lin, Tien-Jen Chen, Miin-Yaw Shyu, Wen-Fung Chang","doi":"10.1536/jhj.45.365","DOIUrl":null,"url":null,"abstract":"<p><p>There is substantial evidence indicating that endogenous opioid peptides are involved in the pathophysiology of myocardial ischemia and reperfusion. We measured the myocardial and peripheral concentrations of beta-endorphin before and following myocardial ischemia and reperfusion during coronary angioplasty. The results indicate that in patients with coronary artery disease, there was an augmented myocardial concentration of beta-endorphin. Moreover, there was an increased peripheral concentration of beta-endorphin following myocardial ischemia and reperfusion. The data support the previous notion that endogenous opioid peptides are involved in the pathophysiology of ischemic heart disease.</p>","PeriodicalId":14717,"journal":{"name":"Japanese heart journal","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2004-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"9","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Japanese heart journal","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1536/jhj.45.365","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 9
Abstract
There is substantial evidence indicating that endogenous opioid peptides are involved in the pathophysiology of myocardial ischemia and reperfusion. We measured the myocardial and peripheral concentrations of beta-endorphin before and following myocardial ischemia and reperfusion during coronary angioplasty. The results indicate that in patients with coronary artery disease, there was an augmented myocardial concentration of beta-endorphin. Moreover, there was an increased peripheral concentration of beta-endorphin following myocardial ischemia and reperfusion. The data support the previous notion that endogenous opioid peptides are involved in the pathophysiology of ischemic heart disease.
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