Iryna G Vasilyeva, Mikhail I Shamaev, Alexandr Ya Glavatskiy, Natalya G Chopick, Natalya P Olexenko, Olga I Tsyubko, Elena S Galanta, Tatyana A Malisheva
{"title":"Detection of polyomavirus DNA in human brain tumors.","authors":"Iryna G Vasilyeva, Mikhail I Shamaev, Alexandr Ya Glavatskiy, Natalya G Chopick, Natalya P Olexenko, Olga I Tsyubko, Elena S Galanta, Tatyana A Malisheva","doi":"","DOIUrl":null,"url":null,"abstract":"<p><strong>Aim: </strong>To investigate surgically resected human brain tumors for the presence of polyomavirus DNA.</p><p><strong>Materials and methods: </strong>65 samples of surgically resected human brain tumors (57 tumors were of neuroectodermal genesis, 4--mesenchimal, 4--metastatic tumors) were examined for the presence of viral DNA by PCR analysis.</p><p><strong>Results: </strong>DNA of polyomaviruses was found in oligodendroligomas (66.7% of cases), oligodendroastrocytomas (66.7% of cases) and glioblastomas (40% of cases). In metastatic tumors viral infection had not been detected. No correlation between the grade of brain tumors and infection with polyomavirus DNA has been revealed.</p><p><strong>Conclusion: </strong>Our data point to importance of investigation of the brain tumors and cerebrospinal fluid for determination of viral infection.</p>","PeriodicalId":77530,"journal":{"name":"Eksperimental'naia onkologiia","volume":"26 1","pages":"78-80"},"PeriodicalIF":0.0000,"publicationDate":"2004-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Eksperimental'naia onkologiia","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Aim: To investigate surgically resected human brain tumors for the presence of polyomavirus DNA.
Materials and methods: 65 samples of surgically resected human brain tumors (57 tumors were of neuroectodermal genesis, 4--mesenchimal, 4--metastatic tumors) were examined for the presence of viral DNA by PCR analysis.
Results: DNA of polyomaviruses was found in oligodendroligomas (66.7% of cases), oligodendroastrocytomas (66.7% of cases) and glioblastomas (40% of cases). In metastatic tumors viral infection had not been detected. No correlation between the grade of brain tumors and infection with polyomavirus DNA has been revealed.
Conclusion: Our data point to importance of investigation of the brain tumors and cerebrospinal fluid for determination of viral infection.
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