[Expression of S100 in oral submucose fibrosis].

Abstract

Objective: To study the expression of S100 in oral submucose fibrosis(OSF).

Methods: Immunohistochemistry assay was performed on 10 cases of OSF, 10 cases of oral epithelial dysplasia (OED) and 8 cases of normal oral epithelium using monoclonal antibody against S100 protein.

Results: S100 did not express in the normal oral muscosal epithelium. The S100 positive nuclear staining was found in 50% of the OSF and OED cases, which was significantly higher than that in the normal oral epithelium (P < 0.05). But the positive staining in the OSF and OED cases had no difference (P > 0.05).

Conclusion: S100 expression is closely related to the development of OSF and OED. The positive staining expression in the OSF and OED cases is the same.