Myo-inositol phosphates in a phosphoinositide complex from kidney

Biochimica et Biophysica Acta (BBA) - Specialized Section on Lipids and Related Subjects Pub Date : 1964-12-02 DOI:10.1016/0926-6542(64)90026-5

F. Andrade, C.G. Huggins

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引用次数: 19

Abstract

1.
1. Chemical studies on the “phosphatido-peptide fraction” from kidney have shown that this material more properly should be called a phosphoinositide complex.
2.
2. Glycerophosphate, inositol mono-, di- and triphosphate were separated from alkaline hydrolysates by means of paper chromatography.
3.
3. Six fractions were obtained by column chromatography from the deacylated phosphoinositide complex and identified as inositol monophosphate, glycerophosphate, inositol diphosphate, glycerylphosphoryl inositol, glycerylphosphoryl inositol phosphate, and glycerylphosphoryl inositol diphosphate.
4.
4. These phosphates, presumably as the inositides, are believed to be responsible for the hgh metabolic activity of this fraction as measured by radiophosphorus.

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肌醇磷酸是来自肾脏的磷酸肌醇复合物

1.1. 对肾中“磷脂肽组分”的化学研究表明，这种物质更恰当地称为磷酸肌肽复合物。用纸层析法从碱性水解物中分离出甘油磷酸、肌醇单磷酸、二磷酸和三磷酸。通过柱层析得到脱酰基磷酸肌醇复合物的6个组分，分别鉴定为单磷酸肌醇、甘油磷酸、二磷酸肌醇、甘油磷酸肌醇、甘油磷酸肌醇磷酸和甘油磷酸肌醇二磷酸。这些磷酸盐，据推测是肌内酯，被认为是由放射性磷测量的这部分高代谢活性的原因。

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Biochimica et Biophysica Acta (BBA) - Specialized Section on Lipids and Related Subjects

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