{"title":"Nitrergic and peptidergic components of NANC relaxations of cat gastric fundus.","authors":"L Chernaeva","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>The mediators of non-adrenergic non-cholinergic (NANC) relaxation of cat gastric fundus were examined in vitro. Electrical field stimulation (EFS, 10 pulses train and 10 s train) induced tetrodotoxin (TTX) sensitive relaxations in the presence of atropine and guanethidine. Relaxation induced by vasoactive intestinal polypeptide (VIP) was abolished by alpha-chymotrypsin (alpha-CT). N omega-nitro-L-arginine (L-NNA) completely inhibited relaxation induced by EFS of 10 pulses train at all frequencies. L-NNA completely inhibited the relaxation induced by EFS of 10 s train at low frequencies but partly that at high frequencies; alpha-CT had an additive to L-NNA inhibitory effect on the relaxation. The results suggest a nitrergic nature of NANC relaxation in cat gastric fundus upon EFS of 10 pulses, and a nitrergic and peptidergic (VIP) nature of relaxations upon EFS of 10 s train.</p>","PeriodicalId":7035,"journal":{"name":"Acta physiologica et pharmacologica Bulgarica","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2000-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Acta physiologica et pharmacologica Bulgarica","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
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Abstract
The mediators of non-adrenergic non-cholinergic (NANC) relaxation of cat gastric fundus were examined in vitro. Electrical field stimulation (EFS, 10 pulses train and 10 s train) induced tetrodotoxin (TTX) sensitive relaxations in the presence of atropine and guanethidine. Relaxation induced by vasoactive intestinal polypeptide (VIP) was abolished by alpha-chymotrypsin (alpha-CT). N omega-nitro-L-arginine (L-NNA) completely inhibited relaxation induced by EFS of 10 pulses train at all frequencies. L-NNA completely inhibited the relaxation induced by EFS of 10 s train at low frequencies but partly that at high frequencies; alpha-CT had an additive to L-NNA inhibitory effect on the relaxation. The results suggest a nitrergic nature of NANC relaxation in cat gastric fundus upon EFS of 10 pulses, and a nitrergic and peptidergic (VIP) nature of relaxations upon EFS of 10 s train.
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