Melatonin modulates mesenteric blood flow and TNFalpha concentrations after lipopolysaccharide challenge.

A Baykal, A B Iskit, E Hamaloglu, M O Guc, G Hascelik, I Sayek
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引用次数: 35

Abstract

Objective: To investigate the effect of various doses of melatonin on reduction in mesenteric blood flow (MBF) and increase in tumour necrosis factor alpha (TNFalpha) concentration caused by injection of lipopolysaccharide (LPS).

Design: University Hospital, Turkey.

Setting: Open experimental study.

Animals: 59 Swiss albino mice.

Interventions: Animals were injected with melatonin solvent or 1, 10, 100, or 500 mg/kg melatonin. Ten minutes later control animals were injected with saline, and the experimental group with LPS.

Main outcome measures: Mesenteric blood flow and serum TNFalpha concentration.

Results: In control animals, 100 and 500 mg/kg melatonin reduced MBF. LPS reduced MBF in solvent, 1, and 10 mg/kg melatonin groups. The concentration of TNFalpha was considerably increased in the mice given LPS. Melatonin reduced this response significantly.

Conclusion: In high doses melatonin directly reduces MBF. It has no protective effect on the LPS-induced decrease in MBF. In lower doses it blocks, but at higher doses reduces, LPS-induced TNFalpha production.

褪黑素在脂多糖攻击后调节肠系膜血流和TNFalpha浓度。
目的:探讨不同剂量褪黑素对注射脂多糖(LPS)引起的肠系膜血流量(MBF)减少和肿瘤坏死因子α (TNFalpha)浓度升高的影响。设计:土耳其大学医院。设置:开放式实验研究。动物:59只瑞士白化小鼠。干预措施:动物注射褪黑素溶剂或1、10、100或500 mg/kg褪黑素。10分钟后,对照组动物注射生理盐水,实验组动物注射LPS。主要观察指标:肠系膜血流量和血清TNFalpha浓度。结果:在对照动物中,100和500 mg/kg褪黑素可降低MBF。LPS降低溶剂组、1和10 mg/kg褪黑素组MBF。在给予LPS的小鼠中,TNFalpha的浓度显著增加。褪黑素显著降低了这种反应。结论:大剂量褪黑素可直接降低MBF。对脂多糖诱导的MBF下降无保护作用。在低剂量时,它会阻断,但在高剂量时,它会减少lps诱导的TNFalpha的产生。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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