Effects of simvastatin on left ventricular hypertrophy and function in rats with aortic stenosis.

Zhongguo yao li xue bao = Acta pharmacologica Sinica Pub Date : 1999-04-01

J D Luo, W W Zhang, G P Zhang, X H Liu, J X Guan

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Abstract

Aim: To investigate the effects of simvastatin (Sim) on left ventricular hypertrophy in rats with pressure-overload cardiac hypertrophy.

Methods: The left ventricular hypertrophy (LVH) of rats was induced by partly occluding abdominal aorta below right renal artery. The rats were given i.g. Sim (1.8 and 3.6 mg.kg-1.d-1) for 8 wk. Three days after operation, left ventricular function was measured. Then the left ventricle (LV) + septum and the right ventricle (RV) were weighed. Hydroxyproline content of LV was measured.

Results: Eight weeks later, in the LVH group, LV weight (LVW), LVW/body weight (BW), LVW/RV weight (RVW), LV ending diastolic pressure (LVEDP), and hydroxyproline content increased by 36%, 51%, 28%, 92%, and 23%, respectively (all P < 0.01) compared with the sham group. LV + dp/dtmax and -dp/dtmax decreased by 39.2% and 39.4% (all P < 0.01). After the rats were given i.g. Sim 3.6 mg.kg-1.d-1, LVW, LVW/BW, LVW/RVW, left ventricle ending diastolic pressure (LVEDP), and hydroxyproline content decreased by 22%, 21%, 23%, 24%, and 11% compared with LVH group (all P < 0.01), LV + dp/dtmax and -dp/dtmax increased by 60% and 32% (all P < 0.01).

Conclusion: Sim inhibited development of LV hypertrophy and improved LV function in rats with aortic stenosis.

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辛伐他汀对主动脉狭窄大鼠左室肥厚及功能的影响。

目的:探讨辛伐他汀对压力过载型心肌肥厚大鼠左室肥厚的影响。方法:部分阻断大鼠右肾动脉下腹主动脉诱导左心室肥厚。给大鼠ig Sim(1.8和3.6 mg.kg-1.d-1) 8周。术后3 d测量左心室功能。然后对左心室(LV) +间隔、右心室(RV)进行称重。测定左心室羟脯氨酸含量。结果:8周后，LVH组左室重量(LVW)、左室重量/体重(BW)、左室重量/右室重量(RVW)、左室舒张末压(LVEDP)、羟脯氨酸含量分别较假手术组升高36%、51%、28%、92%、23%(均P < 0.01)。LV + dp/dtmax、-dp/dtmax降低39.2%、39.4% (P均< 0.01)。大鼠ig Sim 3.6 mg.kg-1。与LVH组相比，d-1、LVW、LVW/BW、LVW/RVW、左室舒张末压(LVEDP)、羟脯氨酸含量分别降低22%、21%、23%、24%、11% (P < 0.01)， LV + dp/dtmax、-dp/dtmax分别升高60%、32% (P < 0.01)。结论:辛可抑制主动脉瓣狭窄大鼠左室肥厚的发生，改善左室功能。

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Zhongguo yao li xue bao = Acta pharmacologica Sinica

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