Pharmacokinetics of atenolol enantiomers in 12 Chinese healthy men.

Zhongguo yao li xue bao = Acta pharmacologica Sinica Pub Date : 1999-04-01

X M Wang, X Y Yu, S G Lin

引用次数: 0

Abstract

Aim: To study the pharmacokinetics of atenolol (Ate) stereoisomers in Chinese.

Method: A single oral dose of 100 mg of racemic Ate tablets were given to 12 healthy volunteers of Han nationality. Plasma and urine concentrations were determined by the reversed phase HPLC method.

Results: The disposition of d-Ate and l-Ate was conformed to one-compartment model. Maximal plasma concentration (Cmax): l-Ate (331 +/- 79) micrograms.L-1, d-Ate (342 +/- 78) micrograms.L-1. Area under blood concentration-time curve (AUC): d-Ate (2635 +/- 610) micrograms.h.L-1, l-Ate (2442 +/- 588) micrograms.h.L-1. Renal clearance (Clr): l-Ate (6.9 +/- 1.2) L.h-1, d-Ate (6.5 +/- 1.3) L.h-1.

Conclusion: The disposition of Ate stereoisomers is of stereoselectivity.

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阿替洛尔对映体在12名中国健康男性体内的药动学。

目的:研究阿替洛尔(Ate)立体异构体在中国人体内的药动学。方法:对12名汉族健康志愿者口服消旋酸酯片100 mg。采用反相高效液相色谱法测定血浆和尿液浓度。结果:d-Ate和l-Ate的分布符合单室模型。最大血浆浓度(Cmax): l-Ate(331 +/- 79)微克。L-1, d-Ate(342 +/- 78)微克，L-1。血浓度-时间曲线下面积(AUC): d-Ate(2635 +/- 610)µg .h。L-1, l-Ate(2442 +/- 588)微克。肾清除率(Clr): l-Ate (6.9 + / - 1.2) L.h-1 d-Ate L.h-1(6.5 + / - 1.3)。结论:Ate立体异构体具有立体选择性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Zhongguo yao li xue bao = Acta pharmacologica Sinica

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