[Immunohistochemical study of cytokeratin and vimentin expression in mixed type of adenocarcinoma and squamous cell carcinoma].

Nihon Sanka Fujinka Gakkai zasshi Pub Date : 1996-10-01
T Yuasa
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Abstract

To clarify the pattern of cytokeratin and vimentin expression in mixed adenocarcinoma and squamous cell carcinoma of the uterine cervix, twenty-three cases of formalin-fixed paraffin-embedded specimen were examined immunohistochemically using a panel of four different monoclonal anti-cytokeratin antibodies and anti-vimentin antibody. Fifty-seven cases of benign or malignant tissue were selected for controls. The results were summarized as follows. 1) In four cases of co-existing adenocarcinoma and squamous cell carcinoma, their immunostaining patterns were compatible with original histological cell type. 2) In four cases of adenoacanthoma, high molecular weight-cytokeratin (HCK) was positive in each acanthomatous component and only a small part of one adenocarcinomatous component. 3) In twelve cases of cervical adenosquamous carcinoma, HCK were positive in four adenocarcinomatous components. Out of eight cases with non-stained adenocarcinomatous components, six cases showed negativity for HCK even in the squamous cell carcinomatous component. 4) Though vimentin was negative in all cases of mixed type of cervical carcinoma, some cases of mixed type endometrial carcinoma were stained positively for vimentin. It was indicated from our study that adenosquamous carcinoma of the cervix could originate either in reserve cells or columunar epithelium and that vimentin positive cases could originate in the endometorial gland.

[混合型腺癌和鳞状细胞癌中细胞角蛋白和波形蛋白表达的免疫组化研究]。
为了明确细胞角蛋白和波形蛋白在宫颈混合腺癌和鳞状细胞癌中的表达规律,我们采用四种不同单克隆抗细胞角蛋白抗体和抗波形蛋白抗体对23例经福尔马林固定石蜡包埋的标本进行免疫组织化学检测。选取57例良性或恶性组织作为对照。结果总结如下:1) 4例腺癌和鳞状细胞癌同时存在,其免疫染色模式与原始组织学细胞类型一致。2)在4例腺棘瘤中,高分子量细胞角蛋白(high molecular weight-cytokeratin, HCK)在所有腺棘瘤成分中均呈阳性,仅在一种腺癌成分中呈小部分阳性。3)在12例宫颈腺鳞癌中,HCK在4种腺癌成分中均呈阳性。在8例腺癌成分未染色的病例中,6例甚至在鳞状细胞癌成分中显示HCK阴性。4)混合型宫颈癌中波形蛋白均为阴性,但部分混合型子宫内膜癌中波形蛋白染色呈阳性。我们的研究表明,宫颈腺鳞癌既可以起源于储备细胞,也可以起源于柱状上皮,而波形蛋白阳性的病例可能起源于子宫内膜腺。
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