The c-erbB3/HER3 receptor in human cancer.

Abstract

c-erbB3 is a receptor for NDF/heregulin that can engage in heterodimerization with other type I receptor tyrosine kinases. Despite very limited kinase activity, it can stimulate responses in heterodimers not evoked by other family members. It is overexpressed frequently in several common solid tumours and thus represents a target for new forms of therapies.