Increased expression of sialyl Lewis A and sialyl Lewis X in liver metastases of human colorectal carcinoma.

Invasion & metastasis Pub Date : 1995-01-01
N Yamada, Y S Chung, K Maeda, T Sawada, T Ikehara, H Nishino, M Okuno, M Sowa
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Abstract

Sialyl Lewis A (SLA) and sialyl Lewis X (SLX) have been shown to be specific ligands for endothelial leukocyte adhesion molecule-1 (ELAM-1), and may be involved in the process of adhesion between cancer cells and endothelium. We used immunohistochemical methods to study the expression of SLA, SLX and CEA in both primary tumors and matched metastatic liver lesions of colorectal carcinomas. Specimens from primary tumors and matched liver metastases from 24 patients with colorectal carcinomas were studied immunohistochemically. The degree of expression of CEA in liver metastases was similar to that in primary tumors, but SLA and SLX were expressed on a larger proportion of tumor cells in liver metastases than in primary tumors. Our findings suggest that colorectal carcinoma cells expressing SLA and/or SLX form metastatic liver tumors. They also suggest that expression of SLA and SLX in primary of colorectal carcinoma can be used as a prognostic indicator of metastasis.

结直肠癌肝转移灶中唾液酸Lewis A和唾液酸Lewis X表达增加。
研究表明,Sialyl Lewis A (SLA)和Sialyl Lewis X (SLX)是内皮白细胞粘附分子-1 (ELAM-1)的特异性配体,可能参与了癌细胞与内皮细胞的粘附过程。我们采用免疫组织化学方法研究了SLA、SLX和CEA在结直肠癌原发肿瘤和匹配的转移性肝病变中的表达。本文对24例结直肠癌原发肿瘤和匹配肝转移瘤标本进行了免疫组织化学研究。CEA在肝转移瘤中的表达程度与原发肿瘤相似,但SLA和SLX在肝转移瘤中表达的肿瘤细胞比例高于原发肿瘤。我们的研究结果表明,表达SLA和/或SLX的结直肠癌细胞形成转移性肝肿瘤。提示SLA和SLX在原发结直肠癌中的表达可作为转移的预后指标。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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