Estrogen activates invasiveness of endometrial cancel cells to the interstitium.

Invasion & metastasis Pub Date : 1995-01-01
J Fujimoto, M Hori, S Ichigo, S Morishita, T Tamaya
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Abstract

Invasiveness of endometrial cancer cells such as Ishikawa, HEC-1-A and HHUA cells, to the interstitium was significantly enhanced by estradiol, while medroxyprogesterone acetate (MPA) significantly diminished the estradiol-enhanced invasive potential. All of these endometrial cancer cells possess estrogen receptors. It is suggested that invasiveness to the interstitium, and consequently infiltration to the uterine myometrium (which means local advance) are activated by estradiol via a mechanism related to the estrogen receptor, and that MPA as an antiestrogen agent partly inactivates the invasive ability.

雌激素激活子宫内膜取消细胞对间质的侵袭。
雌二醇可显著增强石川细胞、HEC-1-A细胞、HHUA细胞等子宫内膜癌细胞对间质的侵袭能力,而醋酸甲孕酮(MPA)可显著减弱雌二醇增强的侵袭潜能。所有这些子宫内膜癌细胞都具有雌激素受体。提示雌二醇通过与雌激素受体相关的机制激活了对间质的侵袭,进而浸润到子宫肌层(即局部推进),而MPA作为抗雌激素药物在一定程度上抑制了这种侵袭能力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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