A M Dygaĭ, V V Zhdanov, I A Khlusov, P A Liubavina, E D Gol'dberg
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引用次数: 0
Abstract
The study of bone marrow hemopoiesis, the count of hemopoietic precursor cells, bone marrow structural and functional organization, the level of humoral stimulators and secretion by hemopoiesis-inducing microenvironment (HIM) cells following a single injection of 5-fluorouracil, cyclophosphamide or adriamycin has found out that cytostatic-related changes in hemopoiesis recovery depend primarily on relationships between proliferation and differentiation of hemopoietic cells. These relationships are dictated by the state of HIM cells. Enhanced functional activity of HIM elements in response to hemopoietic tissue damage caused by adriamycin or cyclophosphamide promotes rapid hemopoiesis regeneration. At the same time, 5-fluorouracil gave rise to prolonged bone marrow hypoplasia, severe disorder of microenvironment cell function.
期刊介绍：
The journal publishes original theoretical and clinical studies, lectures, reviews, and practical notes concerning various problems of hematology and clinical and industrial transfusion. The journal provides information on the etiology, pathogenesis, diagnosis and treatment of blood disorders as well as on related non-hematological conditions (internal diseases, poisoning, exposure to ionizing radiation etc.).
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