Enhanced reactivation of nitrous acid treated adenovirus is not associated with enhanced mutagenesis in pretreated with heavy metals HeLa cells

Abstract

The reversion of frequency of an adenovirus 2 temperature-sensitive growth mutant treated with different doses of nitrous acid was determined after infection of control. UV-irradiated, cadmium chloride and zinc chloride treated HeLa cells. No enhanced mutagenesis was observed.