Thyroxine type II 5'-deiodinase activity in pineal and Harderian gland is enhanced by hypothyroidism but is independent of serum thyroxine concentrations during hyperthyroidism.

C Osuna, J M Orta, A Rubio, P Molinero, J M Guerrero
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引用次数: 5

Abstract

1. This paper studies the effect of thyroid status on 5'-D activity in pineal gland, Harderian gland, brown adipose tissue (BAT), pituitary gland, brain frontal cortex (BFC), and cerebellum. 2. Hypothyroidism clearly increased diurnal 5'-D activity in Harderian gland, BAT, pituitary gland, BFC, and cerebellum. In pineal gland, diurnal values of 5'-D activity were not affected by hypothyroidism. 3. Hypothyroidism in adult rats clearly enhanced nocturnal increase of 5'-D activity in pineal and Harderian gland. Congenital hypothyroidism also enhanced the nocturnal increase of 5'-D activity in pineal gland. 4. Hyperthyroidism inhibited 5'-D activity in pituitary gland, BFC, and cerebellum. A small inhibition, although significant, was found in BAT. 5. In pineal and Harderian gland, hyperthyroidism did not inhibit either the basal diurnal values of the enzyme or the nocturnal increase of its activity. 6. Results suggest that, in tissues where 5'D-activity is regulated by adrenergic mechanisms, mostly pineal gland and Harderian gland, the enzyme activity is independent of serum T4 concentrations during hyperthyroidism.

松果体和哈德氏腺的甲状腺素ⅱ型5′-去碘酶活性在甲状腺功能减退时增强,但在甲状腺功能亢进时与血清甲状腺素浓度无关。
1. 本文研究了甲状腺状态对松果体、哈德氏腺、棕色脂肪组织(BAT)、脑垂体、脑额叶皮质(BFC)和小脑中5′-D活性的影响。2. 甲状腺功能减退明显增加哈德氏腺、BAT、脑垂体、BFC和小脑的5′-D活性。在松果体中,5′d活性的日值不受甲状腺功能减退的影响。3.成年大鼠甲状腺功能减退明显增强夜间松果体和哈德氏腺5′-D活性的升高。先天性甲状腺功能减退也增强了夜间松果体5′-D活性的增加。4. 甲状腺机能亢进可抑制脑垂体、BFC和小脑的5′-D活性。在BAT中发现了一个小的抑制,虽然很明显。5. 在松果体和哈德氏腺中,甲亢既没有抑制酶的基础日值,也没有抑制其夜间活性的增加。6. 结果表明,在5′d活性受肾上腺素能机制调节的组织中,主要是松果体和哈德氏腺,甲亢时该酶活性与血清T4浓度无关。
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