[Anti-ulcer effect of the drug OF-743 in an acid model of ulcer formation by the Okabe method].

Abstract

The application of acetic acid (100%) on gastric serosa produces hemorrhagic lesions, erosions and ulcers in the gastric mucosa of rats. Intraperitoneal injections of OF-743, a derivative of sydnonimine during 3 days after the acid application have revealed lesser expressed mucosal lesions: only hemorrhagic lesions and rather small erosions. The lesions degree in rats subjected to the action of OF-743 was 2.7 as compared with 4.4 in control rats without OF-743. Our findings indicate that OF-743 shows not only protective antiulcer action, as it was discovered earlier, but has also curative antiulcer effect.