Application of a hollow fiber membrane cell culture system in medicine.

Abstract

The Tecnomouse system is useful for cultivating transformed cell lines producing MAbs or recombinant proteins, but human tumor cells can also be propagated for autologous immunization protocols or research properties. Lymphokine-activated killer cell production and stem cell proliferation seem to be possible. Moreover, primary human cells of lymphoid organs can be successfully kept viable over long periods of time in a three-dimensional, tissue-like culture. Therefore, the bioreactor is a tool for the in vitro modulation of a variety of human organs.