Brain beta 2-microglobulin levels are elevated in the striatum in Parkinson's disease.

M Mogi, M Harada, T Kondo, P Riederer, T Nagatsu
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引用次数: 95

Abstract

beta 2-Microglobulin (B2-MG) content was measured for the first time in the brain (caudate nucleus, putamen, and cerebral cortex) from control and parkinsonian patients by a highly sensitive sandwich enzyme immunoassay. The concentrations of B2-MG in dopaminergic striatal regions were significantly higher in parkinsonian patients than those in controls, whereas those in the cerebral cortex showed no significant difference between parkinsonian and control subjects. Tumor necrosis factor-alpha (TNF-alpha) concentrations were also increased in the striatum, confirming our previous findings, but not in the cerebral cortex. Since TNF-alpha may induce B2-MG expression, these results suggest that an immunological response may occur in the nigrostriatal dopaminergic regions in Parkinson's disease.

帕金森病患者纹状体中脑β 2微球蛋白水平升高。
采用高灵敏度的三明治酶免疫分析法首次测定了对照和帕金森病患者大脑(尾状核、壳核和大脑皮层)中β 2-微球蛋白(B2-MG)的含量。帕金森病患者多巴胺能纹状体区B2-MG浓度显著高于对照组,而大脑皮层B2-MG浓度在帕金森病患者和对照组之间无显著差异。纹状体中肿瘤坏死因子- α (tnf - α)浓度也增加,证实了我们之前的发现,但在大脑皮层中没有。由于tnf - α可能诱导B2-MG的表达,这些结果表明帕金森病的免疫反应可能发生在黑质纹状体多巴胺能区。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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