{"title":"Continuation therapy with tricyclic antidepressants in relapsing depressive illness.","authors":"R H Mindham","doi":"10.1159/000392256","DOIUrl":null,"url":null,"abstract":"<p><p>Patients who have suffered a depressive illness frequently relapse when treatment is stopped. A controlled study of continued medication after clinical recovery was carried out. Of 92 patients studied, 22% of those who received amitriptyline or imipramine relapsed during 6 months of observation, compared with 50% of those who received placebo. Patients who experienced persistent residual symptoms derived more benefit from the active drug during continuation treatment than those who made a complete recovery from their illness.</p>","PeriodicalId":75593,"journal":{"name":"Bibliotheca psychiatrica","volume":" 160","pages":"49-55"},"PeriodicalIF":0.0000,"publicationDate":"1981-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000392256","citationCount":"4","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Bibliotheca psychiatrica","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1159/000392256","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 4
Abstract
Patients who have suffered a depressive illness frequently relapse when treatment is stopped. A controlled study of continued medication after clinical recovery was carried out. Of 92 patients studied, 22% of those who received amitriptyline or imipramine relapsed during 6 months of observation, compared with 50% of those who received placebo. Patients who experienced persistent residual symptoms derived more benefit from the active drug during continuation treatment than those who made a complete recovery from their illness.
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