Comparative study of the kinetics of 3-hydroxy-3-methylglutaryl coenzyme A reductase and [14C]-acetate incorporation into cholesterol in human lymphocytes stimulated by phytohemagglutinin or sterol efflux.

Biomedicine / [publiee pour l'A.A.I.C.I.G.] Pub Date : 1981-12-01

C Tabacik, M Astruc, M Laporte, B Descomps, A Crastes de Paulet, B Serrou

引用次数: 0

Abstract

The time course of sterol biosynthesis was compared after two different stimulations in normal human lymphocytes: culture either in the presence of phytohemagglutinin (PHA) or in a lipid-depleted medium (i. e. a condition which produces sterol efflux). Stimulation by PHA gives rise to an acute and rapid response in 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase activity and cholesterol synthesis. The sterol efflux induction produces a slower and milder response and the delayed sterol production consists mainly of lathosterol.

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植物血凝素和甾醇外排刺激人淋巴细胞3-羟基-3-甲基戊二酰辅酶A还原酶和[14C]-乙酸掺入胆固醇动力学的比较研究

在正常的人类淋巴细胞中，在两种不同的刺激下，比较了甾醇生物合成的时间过程:在植物血凝素(PHA)存在的培养基中培养或在脂质耗尽的培养基中培养(即产生甾醇外排的条件)。PHA刺激引起3-羟基-3-甲基戊二酰辅酶A (HMG CoA)还原酶活性和胆固醇合成的急性和快速反应。甾醇外排诱导产生的反应较慢且较温和，延迟的甾醇生产主要由胆甾醇组成。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Biomedicine / [publiee pour l'A.A.I.C.I.G.]

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