Evaluation of the clinical efficacy of single daily doses of antidepressants

Abstract

• 1.

  1. In the light of the relationship between administration schedule and compliance, comparison data between divided dose regimen and one-time daily dosage of antidepressant drugs are reviewed in terms of therapeutic and pharmacokinetic equivalence.

• 2.

  2. Divided (b.i.d.) and single (morning) doses of nomifensine (100–200 mg/die) were studied in patients affected with neurotic depression. Clinical results show that the two regimens do not differentiate as for antidepressant eff$\text{i}$cacy and safety.

• 3.

  3. Nomifensine findings are compared to those obtained with amitriptyline (50–150 mg) given in three different schedules (three daily doses, single dose at morning, single dose at night).