{"title":"Chronic effects of PGBx, a polymeric prostaglandin, on blood leukocyte counts.","authors":"E Polis, F W Cope","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>PGBx, a polymeric prostaglandin, in chronic doses therapeutic for hereditary diabetes and hereditary obesity in mice, produces significant increases of blood neutrophils and lymphocytes in normal mice, hereditary diabetic mice, and hereditary obese mice. For lymphocytes, but not for neutrophils, the direction of the PGBx effect reverses at doses above 10 micrograms/g of body weight.</p>","PeriodicalId":20124,"journal":{"name":"Physiological chemistry and physics","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"1982-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Physiological chemistry and physics","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
PGBx, a polymeric prostaglandin, in chronic doses therapeutic for hereditary diabetes and hereditary obesity in mice, produces significant increases of blood neutrophils and lymphocytes in normal mice, hereditary diabetic mice, and hereditary obese mice. For lymphocytes, but not for neutrophils, the direction of the PGBx effect reverses at doses above 10 micrograms/g of body weight.